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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735594
Species: Homo sapiens
RGD Object: Gene
Symbol: LDLR
Name: low density lipoprotein receptor
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LDLRincreases expressionEXP 6480464CTDHydrogen Peroxide results in increased expression of LDLR mRNAPMID:12414654
LDLRmultiple interactionsEXP 6480464CTD[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of LDLR mRNAPMID:18032389
LDLRincreases expressionISOLdlr (Mus musculus)6480464CTDHydrogen Peroxide results in increased expression of LDLR proteinPMID:29499335
LDLRmultiple interactionsISOLdlr (Mus musculus)6480464CTDMetformin inhibits the reaction [Hydrogen Peroxide results in increased expression of LDLR protein]PMID:29499335
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