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GENE - TERM ANNOTATION REPORT

RGD ID: 735591
Species: Homo sapiens
RGD Object: Gene
Symbol: IL10
Name: interleukin 10
Acc ID: DOID:13241
Term: Behcet's disease
Definition: A vasculitis that is characterized by an autoimmune mediated inflammation of the blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Beh%C3%A7et%27s_disease "DO" "DO", http://www.nlm.nih.gov/medlineplus/behcetssyndrome.html "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL10onsetIAGP 14975256RGD  
IL10susceptibilityIAGP 14975131RGDDNA:SNP:promoter:-592A>C (rs1800872) (human) 
IL10 IEP 14975149RGDDNA, protein:hypermethylation, decreased expression:promoter, serum 
IL10disease_progressionIEP 1598628RGD  
IL10treatmentISOIl10 (Mus musculus)7364843RGD  
IL10 EXP 11554173CTDCTD Direct Evidence: marker/mechanismPMID:20622878 PMID:20622879
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