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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735536
Species: Homo sapiens
RGD Object: Gene
Symbol: KRT8
Name: keratin 8
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KRT8increases expressionEXP 6480464CTDTretinoin results in increased expression of KRT8 mRNA; Tretinoin results in increased expression of KRT8 proteinPMID:17034753 PMID:17387344 PMID:21934132
KRT8decreases expressionISOKrt8 (Rattus norvegicus)6480464CTDTretinoin results in decreased expression of KRT8 mRNAPMID:24977338
KRT8increases expressionISOKrt8 (Mus musculus)6480464CTDTretinoin results in increased expression of KRT8 mRNA; Tretinoin results in increased expression of KRT8 proteinPMID:16236135 PMID:7201471
KRT8multiple interactionsISOKrt8 (Mus musculus)6480464CTD[bisphenol F co-treated with Tretinoin] results in decreased expression of KRT8 mRNAPMID:30951980
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