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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735504
Species: Homo sapiens
RGD Object: Gene
Symbol: C3
Name: complement C3
Acc ID: CHEBI:32234
Term: titanium dioxide
Definition: A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.
Chemical ID: MESH:C009495
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
C3increases expressionISOC3 (Mus musculus)6480464CTDtitanium dioxide results in increased expression of C3 mRNAPMID:21259345 PMID:23557971 PMID:27760801
C3increases expressionISOC3 (Rattus norvegicus)6480464CTDtitanium dioxide results in increased expression of C3 mRNAPMID:30012374
C3multiple interactionsISOC3 (Mus musculus)6480464CTD[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of C3 mRNAPMID:29950665
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