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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735341
Species: Homo sapiens
RGD Object: Gene
Symbol: CDKN1A
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:18388
Term: apigenin
Definition: A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7. It induces autophagy in leukaemia cells.
Chemical ID: MESH:D047310
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDKN1Aincreases expressionEXP 6480464CTDApigenin results in increased expression of CDKN1A mRNA; Apigenin results in increased expression of CDKN1A proteinPMID:11790449 PMID:16023288 PMID:19397994 PMID:26872304
CDKN1Amultiple interactionsEXP 6480464CTDApigenin promotes the reaction [CDKN1A protein binds to PCNA protein]; TP53 protein affects the reaction [Apigenin results in increased expression of CDKN1A protein]PMID:11790449 PMID:26872304
CDKN1Aincreases expressionISOCdkn1a (Rattus norvegicus)6480464CTDApigenin results in increased expression of CDKN1A mRNAPMID:31201582
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