GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | NFE2L2 | decreases expression | EXP | | 6480464 | CTD | Arsenic results in decreased expression of NFE2L2 protein | PMID:35821281 | NFE2L2 | increases expression | EXP | | 6480464 | CTD | Arsenic results in increased expression of NFE2L2 mRNA | PMID:35490796 | NFE2L2 | increases methylation | EXP | | 6480464 | CTD | Arsenic results in increased methylation of NFE2L2 promoter | PMID:29247444 | NFE2L2 | multiple interactions | EXP | | 6480464 | CTD | [Arsenic co-treated with Arsenic] results in increased expression of NFE2L2 protein; [Arsenic results in increased abundance of Hydrogen Peroxide] which results in increased expression of and results in increased localization of NFE2L2 protein; [Arsenic results in increased abundance of Hydrogen Peroxide] which results in increased expression of NFE2L2 mRNA; [arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [NFE2L2 protein binds to ATF6 promoter]; [arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [NFE2L2 protein binds to ATF6B promoter]; [arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [NFE2L2 protein binds to CEBPB gene]; [arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [NFE2L2 protein binds to HSPA1B gene]; [arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [NFE2L2 protein binds to HSPA1B promoter]; [arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [NFE2L2 protein binds to UBE2G2 promoter]; [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of and affects the localization of NFE2L2 protein; [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of NFE2L2 mRNA; [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of NFE2L2 protein; [Cacodylic Acid results in increased abundance of Arsenic] which results in increased expression of and affects the localization of NFE2L2 protein; [Cacodylic Acid results in increased abundance of Arsenic] which results in increased expression of NFE2L2 protein; [Folic Acid co-treated with Arsenic] results in increased expression of NFE2L2 mRNA; [NFE2L1 protein alternative form co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of NFE2L2 mRNA; [S-Adenosylmethionine co-treated with Arsenic] results in increased expression of NFE2L2 mRNA; [sodium arsenate results in increased abundance of Arsenic] which affects the localization of NFE2L2 protein; [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of and affects the localization of NFE2L2 protein; [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of NFE2L2 mRNA; [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of NFE2L2 protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of NFE2L2 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of NFE2L2 protein; NFE2L1 protein alternative form promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [[arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of ATF6 mRNA]; NFE2L2 protein affects the reaction [[arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of ATF6B mRNA]; NFE2L2 protein affects the reaction [[sodium arsenate results in increased abundance of Arsenic] which results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Arsenic results in increased expression of CYP2B10 mRNA]; NFE2L2 protein affects the reaction [Arsenic results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Arsenic results in increased expression of NQO1 protein]; NFE2L2 protein affects the reaction [Arsenic results in increased expression of UGT1A1 mRNA]; NFE2L2 protein affects the reaction [Arsenic results in increased expression of UGT1A1 protein]; NFE2L2 protein affects the reaction [Arsenic results in increased expression of UGT1A3 mRNA]; NFE2L2 protein affects the reaction [Arsenic results in increased expression of UGT1A6 mRNA] | PMID:14567983 PMID:32188015 PMID:32525701 PMID:33434570 PMID:35490796 PMID:35625704 PMID:36720308 PMID:36861143 | NFE2L2 | affects binding | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | Arsenic binds to NFE2L2 protein | PMID:19786557 | NFE2L2 | affects response to substance | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | NFE2L2 mRNA affects the susceptibility to Arsenic; NFE2L2 protein affects the susceptibility to Arsenic | PMID:19786557 PMID:23000044 | NFE2L2 | decreases response to substance | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | NFE2L2 results in decreased susceptibility to Arsenic | PMID:19538980 | NFE2L2 | increases activity | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | Arsenic results in increased activity of NFE2L2 protein | PMID:19808700 | NFE2L2 | increases expression | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | Arsenic results in increased expression of NFE2L2 mRNA; Arsenic results in increased expression of NFE2L2 protein | PMID:19786557 PMID:19808700 PMID:23000044 PMID:35523338 | NFE2L2 | multiple interactions | ISO | Nfe2l2 (Rattus norvegicus) | 6480464 | CTD | [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NFE2L2 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NFE2L2 protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of NFE2L2 protein; Melatonin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NFE2L2 protein]; Melatonin promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of NFE2L2 protein]; sulforaphane inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NFE2L2 mRNA]; sulforaphane inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NFE2L2 protein] | PMID:35598369 PMID:37906532 PMID:38229313 | NFE2L2 | multiple interactions | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | [[sodium arsenite results in increased abundance of Arsenic] which co-treated with biochanin A] results in increased expression of NFE2L2 mRNA; [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein; [[sodium arsenite results in increased abundance of Arsenic] which co-treated with epigallocatechin gallate] results in increased expression of NFE2L2 mRNA; [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Phloretin] results in increased expression of NFE2L2 mRNA; [Dexamethasone co-treated with Arsenic] results in increased activity of NFE2L2 protein; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NFE2L2 protein; NFE2L2 mRNA affects the reaction [Arsenic results in increased expression of GCLC mRNA]; NFE2L2 mRNA affects the reaction [Arsenic results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA affects the reaction [Arsenic results in increased expression of NQO1 mRNA]; NFE2L2 mRNA affects the reaction [Arsenic results in increased expression of SRXN1 mRNA]; NFE2L2 protein affects the reaction [Arsenic results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [Arsenic results in increased expression of GCLM protein]; NFE2L2 protein affects the reaction [Arsenic results in increased expression of GSR mRNA]; NFE2L2 protein affects the reaction [Arsenic results in increased expression of GSR protein]; NFE2L2 protein affects the reaction [Arsenic results in increased expression of GSS mRNA]; NFE2L2 protein affects the reaction [Arsenic results in increased expression of GSS protein]; NFE2L2 protein affects the reaction [Arsenic results in increased expression of KRT20 mRNA]; NFE2L2 protein affects the reaction [Arsenic results in increased expression of SIS mRNA]; NFE2L2 protein affects the reaction [Arsenic results in increased expression of SQSTM1 protein] | PMID:23000044 PMID:30114225 PMID:31238026 PMID:33410021 PMID:35523338 PMID:36720308 | | ||||||||||||||||||||||
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