GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nr1h4 | affects abundance | EXP | | 6480464 | CTD | NR1H4 protein affects the abundance of Taurocholic Acid | PMID:30556042 | Nr1h4 | affects response to substance | EXP | | 6480464 | CTD | NR1H4 protein affects the susceptibility to Taurocholic Acid | PMID:30556042 | Nr1h4 | increases expression | EXP | | 6480464 | CTD | Taurocholic Acid results in increased expression of NR1H4 mRNA | PMID:27160211 | Nr1h4 | multiple interactions | EXP | | 6480464 | CTD | [NR1H4 protein affects the susceptibility to Taurocholic Acid] which affects the expression of MYC mRNA; [Taurocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of FGF15 mRNA; NR1H4 gene mutant form promotes the reaction [Taurocholic Acid results in increased expression of CCL2 mRNA]; NR1H4 gene mutant form promotes the reaction [Taurocholic Acid results in increased expression of SERPINE1 mRNA]; NR1H4 gene mutant form promotes the reaction [Taurocholic Acid results in increased phosphorylation of MAPK8 protein]; NR1H4 gene mutant form promotes the reaction [Taurocholic Acid results in increased phosphorylation of MAPK9 protein]; NR1H4 protein affects the reaction [Taurocholic Acid results in decreased expression of CYP7A1 mRNA]; NR1H4 protein affects the reaction [Taurocholic Acid results in decreased expression of PON1 mRNA]; pyrazolanthrone inhibits the reaction [NR1H4 gene mutant form promotes the reaction [Taurocholic Acid results in increased expression of CCL2 mRNA]] | PMID:16284190 PMID:28505368 PMID:30556042 | Nr1h4 | increases activity | ISO | NR1H4 (Homo sapiens) | 6480464 | CTD | Taurocholic Acid results in increased activity of NR1H4 protein | PMID:17567710 | Nr1h4 | increases export | ISO | NR1H4 (Homo sapiens) | 6480464 | CTD | NR1H4 protein results in increased export of Taurocholic Acid | PMID:22961653 | Nr1h4 | increases expression | ISO | NR1H4 (Homo sapiens) | 6480464 | CTD | Taurocholic Acid results in increased expression of NR1H4 mRNA | PMID:18706437 | Nr1h4 | multiple interactions | ISO | NR1H4 (Homo sapiens) | 6480464 | CTD | epiallopregnanolone sulfate inhibits the reaction [NR1H4 protein results in increased export of Taurocholic Acid]; GW 4064 promotes the reaction [NR1H4 protein results in increased export of Taurocholic Acid]; Taurocholic Acid binds to and results in increased activity of NR1H4 protein | PMID:19445040 PMID:22961653 | | ||||||||||||||||||||||
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