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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732909
Species: Homo sapiens
RGD Object: Gene
Symbol: AKT1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:16196
Term: oleic acid
Definition: An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.
Chemical ID: MESH:D019301
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKT1decreases phosphorylationEXP 6480464CTDOleic Acid results in decreased phosphorylation of AKT1 proteinPMID:25536389
AKT1multiple interactionsEXP 6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Oleic Acid results in decreased phosphorylation of AKT1 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [NAD inhibits the reaction [Oleic Acid results in decreased phosphorylation of AKT1 protein]]; [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride co-treated with NAD] inhibits the reaction [Oleic Acid results in decreased phosphorylation of AKT1 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Oleic Acid results in decreased phosphorylation of AKT1 protein]; NAD inhibits the reaction [Oleic Acid results in decreased phosphorylation of AKT1 protein]; PARP1 protein affects the reaction [Oleic Acid results in decreased phosphorylation of AKT1 protein]PMID:25536389
AKT1multiple interactionsISOAkt1 (Rattus norvegicus)6480464CTDOleic Acid inhibits the reaction [IRS2 results in increased phosphorylation of and results in increased activity of AKT1 protein]PMID:14604813
AKT1multiple interactionsISOAkt1 (Mus musculus)6480464CTD[Oleic Acid co-treated with Palmitic Acid] results in decreased phosphorylation of AKT1 proteinPMID:26847930
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