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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732775
Species: Homo sapiens
RGD Object: Gene
Symbol: ALOX5
Name: arachidonate 5-lipoxygenase
Acc ID: CHEBI:28666
Term: leukotriene D4
Definition: A leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and a L-cysteinylglycinyl group at position 6 (6R).
Chemical ID: MESH:D017998
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ALOX5increases abundanceEXP 6480464CTDALOX5 protein results in increased abundance of Leukotriene D4PMID:12629151
ALOX5multiple interactionsEXP 6480464CTD[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene D4PMID:10764316
ALOX5multiple interactionsISOAlox5 (Mus musculus)6480464CTDALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene D4]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene D4]]PMID:12794006
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