Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:leukotriene D4
go back to main search page
Accession:CHEBI:28666 term browser browse the term
Definition:A leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and a L-cysteinylglycinyl group at position 6 (6R).
Synonyms:exact_synonym: S-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-L-cysteinylglycine
 related_synonym: (R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-L-cysteinyl)glycine;   5S-hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11E,14Z-eicosatetraenoic acid;   Formula=C25H40N2O6S;   InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1;   InChIKey=YEESKJGWJFYOOK-IJHYULJSSA-N;   LTD4;   SMILES=CCCCC\\C=C/C\\C=C/C=C/C=C/[C@@H](SC[C@H](N)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O
 alt_id: CHEBI:25026;   CHEBI:6423
 xref: CAS:73836-78-9 "ChemIDplus";   CAS:73836-78-9 "KEGG COMPOUND";   HMDB:HMDB0003080;   KEGG:C05951;   LIPID_MAPS_instance:LMFA03020006 "LIPID MAPS"
 xref_mesh: MESH:D017998
 xref: PMID:23825762 "Europe PMC";   PMID:9160411 "Europe PMC";   Reaxys:4726738 "Reaxys";   Wikipedia:Leukotriene_D4
 cyclic_relationship: is_conjugate_acid_of CHEBI:63166


show annotations for term's descendants       view all columns           Sort by:
 
leukotriene D4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ALOX5 arachidonate 5-lipoxygenase JBrowse link 10 45,374,166 45,446,121 RGD:6480464
G CSF2 colony stimulating factor 2 JBrowse link 5 132,073,789 132,076,170 RGD:6480464
G CXCL8 C-X-C motif chemokine ligand 8 JBrowse link 4 73,740,569 73,743,716 RGD:6480464
G CYSLTR1 cysteinyl leukotriene receptor 1 JBrowse link X 78,271,468 78,327,691 RGD:6480464
G CYSLTR2 cysteinyl leukotriene receptor 2 JBrowse link 13 48,653,929 48,711,226 RGD:6480464
G FAS Fas cell surface death receptor JBrowse link 10 88,968,429 89,017,059 RGD:6480464
G GPR17 G protein-coupled receptor 17 JBrowse link 2 127,645,864 127,652,639 RGD:6480464
G ICAM1 intercellular adhesion molecule 1 JBrowse link 19 10,271,120 10,286,615 RGD:6480464
G IL12A interleukin 12A JBrowse link 3 159,988,835 159,996,019 RGD:6480464
G IL12B interleukin 12B JBrowse link 5 159,314,780 159,330,487 RGD:6480464
G IL13 interleukin 13 JBrowse link 5 132,656,522 132,661,110 RGD:6480464
G IL5 interleukin 5 JBrowse link 5 132,539,194 132,556,864 RGD:6480464
G IL6 interleukin 6 JBrowse link 7 22,725,889 22,732,002 RGD:6480464
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 22 21,759,657 21,867,680 RGD:6480464
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 16 30,114,105 30,123,309 RGD:6480464
G MGST1 microsomal glutathione S-transferase 1 JBrowse link 12 16,347,142 16,377,192 RGD:6480464
G MMP9 matrix metallopeptidase 9 JBrowse link 20 46,008,908 46,016,561 RGD:6480464
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming JBrowse link 11 1,157,953 1,201,138 RGD:6480464
G PDGFRB platelet derived growth factor receptor beta JBrowse link 5 150,113,839 150,155,845 RGD:6480464
G PTGS1 prostaglandin-endoperoxide synthase 1 JBrowse link 9 122,369,906 122,395,703 RGD:6480464
G SELP selectin P JBrowse link 1 169,588,849 169,630,125 RGD:6480464
G SRC SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 20 37,344,685 37,405,432 RGD:6480464
G TGFB1 transforming growth factor beta 1 JBrowse link 19 41,330,323 41,353,922 RGD:6480464
G TNF tumor necrosis factor JBrowse link 6 31,575,565 31,578,336 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23677
    role 23565
      application 22946
        pharmaceutical 22484
          drug 22484
            bronchoconstrictor agent 64
              leukotriene D4 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 23677
    subatomic particle 23624
      composite particle 23624
        hadron 23624
          baryon 23624
            nucleon 23624
              atomic nucleus 23624
                atom 23624
                  main group element atom 23441
                    p-block element atom 23441
                      carbon group element atom 23142
                        carbon atom 23118
                          organic molecular entity 23118
                            organic group 21814
                              organic divalent group 21784
                                organodiyl group 21784
                                  carbonyl group 21756
                                    carbonyl compound 21756
                                      carboxylic acid 20776
                                        monocarboxylic acid 19753
                                          fatty acid 18115
                                            unsaturated fatty acid 910
                                              polyunsaturated fatty acid 662
                                                fatty acid 20:4 315
                                                  icosatetraenoic acid 315
                                                    icosa-7,9,11,14-tetraenoic acid 45
                                                      leukotriene D4 24
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.