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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732528
Species: Mus musculus
RGD Object: Gene
Symbol: Nat2
Name: N-acetyltransferase 2 (arylamine N-acetyltransferase)
Acc ID: CHEBI:6030
Term: isoniazide
Definition: A carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine.
Chemical ID: MESH:D007538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nat2affects acetylationISONAT2 (Homo sapiens)6480464CTDNAT2 protein polymorphism affects the acetylation of IsoniazidPMID:36040704
Nat2affects metabolic processingISONAT2 (Homo sapiens)6480464CTDNAT2 protein affects the metabolism of Isoniazid; NAT2 protein polymorphism affects the metabolism of IsoniazidPMID:15546075 PMID:15627487 PMID:15908628
Nat2affects response to substanceISONAT2 (Homo sapiens)6480464CTDNAT2 gene polymorphism affects the susceptibility to Isoniazid; NAT2 gene SNP affects the susceptibility to IsoniazidPMID:11379777 PMID:11915035 PMID:15618686 PMID:20485159 PMID:25794903
Nat2decreases acetylationISONAT2 (Homo sapiens)6480464CTDNAT2 gene polymorphism results in decreased acetylation of IsoniazidPMID:18544910
Nat2decreases expressionISONat2 (Rattus norvegicus)6480464CTDIsoniazid results in decreased expression of NAT2 mRNAPMID:28619387
Nat2increases acetylationISONAT2 (Homo sapiens)6480464CTDNAT2 protein polymorphism results in increased acetylation of Isoniazid; NAT2 protein results in increased acetylation of IsoniazidPMID:11379777 PMID:15565348 PMID:15627487 PMID:17973219 PMID:36040704
Nat2increases metabolic processingISONAT2 (Homo sapiens)6480464CTDNAT2 protein results in increased metabolism of IsoniazidPMID:16531626 PMID:16847467 PMID:17509624 PMID:30358977
Nat2multiple interactionsISONat2 (Rattus norvegicus)6480464CTD[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA]PMID:28619387
Nat2multiple interactionsISONAT2 (Homo sapiens)6480464CTD[NAT2 gene polymorphism results in decreased acetylation of Isoniazid] which results in decreased abundance of acetylisoniazid; [NAT2 gene polymorphism results in decreased metabolism of Isoniazid] which results in increased abundance of hydrazinePMID:18544910
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