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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732503
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases expressionISOMAPK1 (Homo sapiens)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of MAPK1 proteinPMID:31675489
Mapk1increases phosphorylationISOMapk1 (Rattus norvegicus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether analog results in increased phosphorylation of MAPK1 protein; 2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of MAPK1 proteinPMID:20171977 PMID:33581290
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