Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	732502
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	MAPK1
Name:	mitogen-activated protein kinase 1

Acc ID:	CHEBI:31823
Term:	mercury dichloride
Definition:	A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.
Chemical ID:	MESH:D008627

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
MAPK1	increases phosphorylation	EXP		6480464	CTD	Mercuric Chloride results in increased phosphorylation of MAPK1 protein	PMID:20951154
MAPK1	multiple interactions	EXP		6480464	CTD	[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Mercuric Chloride; Acetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased phosphorylation of MAPK1 protein]; Mercuric Chloride inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]	PMID:19327394 PMID:20951154 PMID:22910795
MAPK1	increases phosphorylation	ISO	Mapk1 (Rattus norvegicus)	6480464	CTD	Mercuric Chloride results in increased phosphorylation of MAPK1 protein	PMID:23415682
MAPK1	increases phosphorylation	ISO	Mapk1 (Mus musculus)	6480464	CTD	Mercuric Chloride analog results in increased phosphorylation of MAPK1 protein; Mercuric Chloride results in increased phosphorylation of MAPK1 protein	PMID:10861847 PMID:21373768 PMID:29981841
MAPK1	multiple interactions	ISO	Mapk1 (Mus musculus)	6480464	CTD	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Mercuric Chloride analog results in increased phosphorylation of MAPK1 protein]; Mercuric Chloride inhibits the reaction [CD22 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]	PMID:17656488 PMID:29981841

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