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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732481
Species: Mus musculus
RGD Object: Gene
Symbol: Hspb1
Name: heat shock protein 1
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspb1multiple interactionsEXP 6480464CTDSB 203580 inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of HSPB1 protein]PMID:21457723
Hspb1decreases phosphorylationISOHSPB1 (Homo sapiens)6480464CTDSB 203580 results in decreased phosphorylation of HSPB1 proteinPMID:20864298
Hspb1multiple interactionsISOHspb1 (Rattus norvegicus)6480464CTD[SB 203580 inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased phosphorylation of HSPB1 protein; SB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of HSPB1 protein]; SB 203580 inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of HSPB1 protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of HSPB1 protein]PMID:20864298 PMID:22000993 PMID:36049518
Hspb1multiple interactionsISOHSPB1 (Homo sapiens)6480464CTDSB 203580 inhibits the reaction [IL1B protein results in increased phosphorylation of HSPB1 protein]; SB 203580 inhibits the reaction [Methotrexate results in increased expression of HSPB1 protein]PMID:10903806 PMID:19100307
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