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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732441
Species: Homo sapiens
RGD Object: Gene
Symbol: TXN
Name: thioredoxin
Acc ID: CHEBI:26523
Term: reactive oxygen species
Definition: Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
Chemical ID: MESH:D017382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TXNmultiple interactionsEXP 6480464CTDTXN protein inhibits the reaction [Indomethacin results in increased abundance of Reactive Oxygen Species]; TXN protein inhibits the reaction [Oxygen results in increased chemical synthesis of Reactive Oxygen Species]PMID:17654042 PMID:20812253
TXNmultiple interactionsISOTxn1 (Mus musculus)6480464CTDReactive Oxygen Species affects the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]PMID:16449798
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