GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk8 | multiple interactions | ISO | MAPK8 (Homo sapiens) | 150429751 | RGD | N-acetyl-L-cysteine inhibits the reaction [Curcumin increases phosphorylation of MAPK8 protein in uterine cervix] | | Mapk8 | multiple interactions | EXP | | 6480464 | CTD | [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased phosphorylation of MAPK8 protein]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]]; Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Biological Products results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [cadmium sulfate results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Dopamine results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [maduramicin results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Oxidopamine promotes the reaction [MAPK8 protein binds to and results in increased phosphorylation of JUN protein]]; Acetylcysteine inhibits the reaction [zinc chloride results in increased activity of MAPK8 protein] | PMID:10397638 PMID:11306679 PMID:14687664 PMID:17481858 PMID:19654923 PMID:25531190 PMID:29248572 PMID:29458170 PMID:30796935 PMID:31229567 PMID:35833596 PMID:37598316 | Mapk8 | decreases phosphorylation | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | Acetylcysteine results in decreased phosphorylation of MAPK8 protein | PMID:24735948 | Mapk8 | multiple interactions | ISO | Mapk8 (Rattus norvegicus) | 6480464 | CTD | Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [aureusidin results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [cypermethrin results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Palmitic Acid results in increased expression of MAPK8 mRNA]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased expression of MAPK8 mRNA] | PMID:17041759 PMID:19760616 PMID:21145380 PMID:22085843 PMID:22767315 PMID:30259999 PMID:30633982 PMID:31790703 PMID:35512476 PMID:36813253 | Mapk8 | multiple interactions | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | Acetylcysteine inhibits the reaction [2,3,5-(triglutathion-S-yl)hydroquinone results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [8-bromo-7-methoxychrysin results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [[Bortezomib co-treated with Butyrates] results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [[Bortezomib co-treated with Vorinostat] results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [APP protein results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Asbestos, Serpentine results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [butein results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Butyric Acid results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [cholix toxin, Vibrio cholerae results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [efavirenz metabolite results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [efavirenz results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [eriocitrin results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [isoliensinine results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [longikaurin A results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Sodium Selenite results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [Sodium Selenite results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Spermine results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK8 protein] | PMID:12684028 PMID:12902192 PMID:15173093 PMID:18412143 PMID:18728404 PMID:20121705 PMID:20632440 PMID:21135414 PMID:21391979 PMID:21958719 PMID:23836369 PMID:24386346 PMID:24735948 PMID:26219228 PMID:26514923 PMID:28087840 PMID:28600122 PMID:28801140 PMID:30550853 PMID:30766661 PMID:31313457 PMID:33039870 PMID:34510229 PMID:34520753 PMID:34724282 PMID:34861471 PMID:35122928 PMID:35130734 PMID:35689653 PMID:36070022 | | ||||||||||||||||||||||
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