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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732221
Species: Homo sapiens
RGD Object: Gene
Symbol: GSR
Name: glutathione-disulfide reductase
Acc ID: CHEBI:6925
Term: microcystin-LR
Definition: A microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl,L-arginyl, 2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle. Produced by the cyanobacterium Microcystis aeruginosa, it is the most studied of the microcystins.
Chemical ID: MESH:C057862
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSRdecreases activityEXP 6480464CTDcyanoginosin LR results in decreased activity of GSR proteinPMID:32061150
GSRmultiple interactionsEXP 6480464CTDThioctic Acid inhibits the reaction [cyanoginosin LR results in decreased activity of GSR protein]PMID:32061150
GSRincreases activityISOGsr (Rattus norvegicus)6480464CTDcyanoginosin LR results in increased activity of GSR proteinPMID:25410294
GSRincreases expressionISOGsr (Mus musculus)6480464CTDcyanoginosin LR results in increased expression of GSR mRNAPMID:17654400
GSRmultiple interactionsISOGsr (Rattus norvegicus)6480464CTD[cyanoginosin LR co-treated with Buthionine Sulfoximine] results in increased activity of GSR proteinPMID:25410294
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