GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | GSR | decreases activity | EXP | | 6480464 | CTD | Carmustine results in decreased activity of GSR protein | PMID:12632252 PMID:15857610 PMID:18155673 PMID:19401447 PMID:19668867 PMID:19856331 | GSR | multiple interactions | EXP | | 6480464 | CTD | [Carmustine results in decreased activity of GSR protein] which results in increased susceptibility to Doxorubicin; [Carmustine results in decreased activity of GSR protein] which results in increased susceptibility to zinc chloride; Glutathione Disulfide inhibits the reaction [Carmustine results in decreased activity of GSR protein]; NADP affects the reaction [Carmustine results in decreased activity of GSR protein] | PMID:12632252 PMID:16160061 PMID:19668867 | GSR | decreases activity | ISO | Gsr (Rattus norvegicus) | 6480464 | CTD | Carmustine results in decreased activity of GSR protein | PMID:12433058 PMID:15104113 PMID:17382203 PMID:18528683 PMID:20046642 PMID:2116959 PMID:21600974 | GSR | decreases activity | ISO | Gsr (Mus musculus) | 6480464 | CTD | Carmustine results in decreased activity of GSR protein | PMID:15857610 PMID:17498860 | GSR | multiple interactions | ISO | Gsr (Rattus norvegicus) | 6480464 | CTD | [Buthionine Sulfoximine co-treated with Carmustine] results in decreased activity of GSR protein; [Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of GSR protein; [Carmustine results in decreased activity of GSR protein] which results in increased susceptibility to Streptozocin; [Carmustine results in decreased activity of GSR protein] which results in increased uptake of Calcium; MT2 protein inhibits the reaction [Carmustine results in decreased activity of GSR protein]; Zinc Sulfate inhibits the reaction [Carmustine results in decreased activity of GSR protein] | PMID:12967637 PMID:15321730 PMID:15720826 PMID:16288907 PMID:18528683 PMID:20046642 | GSR | multiple interactions | ISO | Gsr (Mus musculus) | 6480464 | CTD | [[Carmustine results in decreased activity of GSR protein] which co-treated with Oligodeoxyribonucleotides analog] results in increased abundance of Glutathione Disulfide; [[Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein] which results in increased abundance of Glutathione Disulfide; [Carmustine results in decreased activity of GSR protein] which results in decreased susceptibility to chromium hexavalent ion; [Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein | PMID:12114195 PMID:12477282 PMID:17498860 | | ||||||||||||||||||||||
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