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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732179
Species: Homo sapiens
RGD Object: Gene
Symbol: POLG
Name: DNA polymerase gamma, catalytic subunit
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
POLGdecreases expressionISOPolg (Rattus norvegicus)6480464CTDRotenone results in decreased expression of POLG proteinPMID:33515431
POLGmultiple interactionsISOPolg (Rattus norvegicus)6480464CTDZLN005 inhibits the reaction [Rotenone results in decreased expression of POLG protein]PMID:33515431
POLGmultiple interactionsISOPolg (Mus musculus)6480464CTDRotenone promotes the reaction [POLG gene mutant form results in increased chemical synthesis of Superoxides]PMID:30038268
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