GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PCNA | affects expression | ISO | Pcna (Rattus norvegicus) | 6480464 | CTD | Carbon Tetrachloride affects the expression of PCNA protein | PMID:16092975 | PCNA | decreases expression | ISO | Pcna (Rattus norvegicus) | 6480464 | CTD | Carbon Tetrachloride results in decreased expression of PCNA mRNA | PMID:19224547 | PCNA | increases expression | ISO | Pcna (Rattus norvegicus) | 6480464 | CTD | Carbon Tetrachloride results in increased expression of PCNA mRNA; Carbon Tetrachloride results in increased expression of PCNA protein | PMID:16609998 PMID:17032414 PMID:17166617 PMID:18481824 | PCNA | increases expression | ISO | Pcna (Mus musculus) | 6480464 | CTD | Carbon Tetrachloride results in increased expression of PCNA mRNA; Carbon Tetrachloride results in increased expression of PCNA protein | PMID:14999682 PMID:15056808 PMID:19887370 PMID:19913046 PMID:24639359 PMID:24646716 PMID:25445725 PMID:25566828 PMID:25656916 PMID:30056145 PMID:31919559 | PCNA | multiple interactions | ISO | Pcna (Rattus norvegicus) | 6480464 | CTD | [Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of PCNA protein; [Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of PCNA mRNA; Dalteparin promotes the reaction [Carbon Tetrachloride results in increased expression of PCNA protein]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of PCNA protein]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of PCNA mRNA]; PLAU protein promotes the reaction [Carbon Tetrachloride results in increased expression of PCNA protein]; Silymarin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of PCNA mRNA]; thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of PCNA mRNA]; WeiJia promotes the reaction [Carbon Tetrachloride results in increased expression of PCNA protein] | PMID:16609998 PMID:17166617 PMID:18481824 PMID:28935427 PMID:29923357 | PCNA | multiple interactions | ISO | Pcna (Mus musculus) | 6480464 | CTD | ADAM8 protein affects the reaction [Carbon Tetrachloride results in increased expression of PCNA mRNA]; ADAM8 protein affects the reaction [Carbon Tetrachloride results in increased expression of PCNA protein]; Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of PCNA protein]; ginsan promotes the reaction [Carbon Tetrachloride results in increased expression of PCNA protein]; HTS 466284 promotes the reaction [Carbon Tetrachloride results in increased expression of PCNA protein]; IL6 protein affects the reaction [Carbon Tetrachloride results in increased expression of PCNA protein]; Lipids inhibits the reaction [Carbon Tetrachloride results in increased expression of PCNA protein]; myricitrin promotes the reaction [Carbon Tetrachloride results in increased expression of PCNA protein]; OSM protein affects the reaction [IL6 protein affects the reaction [Carbon Tetrachloride results in increased expression of PCNA protein]] | PMID:14999682 PMID:19913046 PMID:24646716 PMID:25445725 PMID:25566828 PMID:25656916 PMID:30056145 | | ||||||||||||||||||||||
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