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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732035
Species: Homo sapiens
RGD Object: Gene
Symbol: SP1
Name: Sp1 transcription factor
Acc ID: CHEBI:28216
Term: methylmercury chloride
Definition: A chlorine molecular entity that has formula CH3ClHg.
Chemical ID: MESH:C004925
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SP1decreases expressionEXP 6480464CTDmethylmercuric chloride results in decreased expression of SP1 mRNAPMID:28001369
SP1decreases expressionISOSp1 (Rattus norvegicus)6480464CTDmethylmercuric chloride results in decreased expression of SP1 proteinPMID:28736149
SP1multiple interactionsISOSp1 (Mus musculus)6480464CTD[[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of SP1 protein; [methylmercuric chloride co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 proteinPMID:32179164
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