GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ppard | increases response to substance | EXP | | 6480464 | CTD | PPARD results in increased susceptibility to nimesulide | PMID:21159610 | Ppard | multiple interactions | EXP | | 6480464 | CTD | [[(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid binds to and results in increased activity of PPARD protein] co-treated with [nimesulide results in decreased activity of PTGS2 protein]] results in increased expression of KRT10 mRNA; [[nimesulide results in decreased activity of PTGS2 protein] co-treated with [(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid binds to and results in increased activity of PPARD protein]] results in decreased abundance of Dinoprostone; nimesulide results in increased activity of and results in increased expression of PPARD; PPARD protein affects the reaction [[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone]; PPARD protein mutant form inhibits the reaction [[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone] | PMID:19748995 PMID:21159610 | Ppard | increases expression | ISO | PPARD (Homo sapiens) | 6480464 | CTD | nimesulide results in increased expression of PPARD mRNA; nimesulide results in increased expression of PPARD protein | PMID:19415698 | | ||||||||||||||||||||||
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