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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731904
Species: Homo sapiens
RGD Object: Gene
Symbol: KCNJ8
Name: potassium inwardly rectifying channel subfamily J member 8
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KCNJ8decreases expressionISOKcnj8 (Rattus norvegicus)6480464CTDLipopolysaccharides results in decreased expression of KCNJ8 proteinPMID:27246103
KCNJ8increases response to substanceISOKcnj8 (Mus musculus)6480464CTDKCNJ8 gene mutant form results in increased susceptibility to LipopolysaccharidesPMID:18026101
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