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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731729
Species: Mus musculus
RGD Object: Gene
Symbol: Casp1
Name: caspase 1
Acc ID: CHEBI:38635
Term: 3-methyladenine
Definition: A methyladenine that is adenine substituted with a methyl group at position N-3.
Chemical ID: MESH:C025946
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp1multiple interactionsEXP 6480464CTD3-methyladenine affects the reaction [[HU 308 co-treated with Dextran Sulfate] affects the cleavage of CASP1 protein]PMID:27611972
Casp1multiple interactionsISOCasp1 (Rattus norvegicus)6480464CTD3-methyladenine promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein modified form]PMID:31586597
Casp1multiple interactionsISOCASP1 (Homo sapiens)6480464CTD3-methyladenine inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; 3-methyladenine inhibits the reaction [Patulin results in increased expression of CASP1 protein]; 3-methyladenine promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; 3-methyladenine promotes the reaction [Acrolein results in increased expression of CASP1 protein]PMID:30205151 PMID:30237538 PMID:33217525 PMID:34238121
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