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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731729
Species: Mus musculus
RGD Object: Gene
Symbol: Casp1
Name: caspase 1
Acc ID: CHEBI:5441
Term: glyburide
Definition: An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
Chemical ID: MESH:D005905
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp1multiple interactionsEXP 6480464CTDGlyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [Ozone results in increased cleavage of CASP1 protein]PMID:32167222 PMID:32375810 PMID:34052309
Casp1multiple interactionsISOCasp1 (Rattus norvegicus)6480464CTD[Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [Paraquat results in increased expression of CASP1 protein]PMID:25338942 PMID:32522579 PMID:32860822 PMID:36999408
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