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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731712
Species: Homo sapiens
RGD Object: Gene
Symbol: RB1
Name: RB transcriptional corepressor 1
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RB1decreases phosphorylationEXP 6480464CTDfulvestrant results in decreased phosphorylation of RB1 proteinPMID:21367843
RB1multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of RB1 gene; [CDK6 affects the susceptibility to Fulvestrant] which affects the phosphorylation of RB1 protein; Fulvestrant inhibits the reaction [bisphenol S results in increased phosphorylation of RB1 protein]; Fulvestrant promotes the reaction [RB1 protein binds to CCNA2 promoter]; Fulvestrant promotes the reaction [RB1 protein binds to PLK1 promoter]; Fulvestrant promotes the reaction [RB1 protein binds to RNR2 promoter]; RB1 mutant form inhibits the reaction [Fulvestrant promotes the reaction [SIN3B protein binds to CCNA2 promoter]]; RB1 mutant form inhibits the reaction [Fulvestrant promotes the reaction [SIN3B protein binds to PLK1 promoter]]; RB1 mutant form inhibits the reaction [Fulvestrant promotes the reaction [SIN3B protein binds to RNR2 promoter]]PMID:21367843 PMID:24169358 PMID:30684532 PMID:31601247
RB1multiple interactionsISORb1 (Rattus norvegicus)6480464CTDFulvestrant inhibits the reaction [Estradiol results in increased expression of RB1 mRNA]PMID:36931579
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