GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nox4 | multiple interactions | EXP | | 6480464 | CTD | [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of NOX4 protein; Glutathione inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of NOX4 protein] | PMID:36689145 | Nox4 | increases expression | ISO | Nox4 (Rattus norvegicus) | 6480464 | CTD | sodium arsenite results in increased expression of NOX4; sodium arsenite results in increased expression of NOX4 mRNA; sodium arsenite results in increased expression of NOX4 protein | PMID:21605584 PMID:24062023 PMID:25218292 PMID:26079204 | Nox4 | increases expression | ISO | NOX4 (Homo sapiens) | 6480464 | CTD | sodium arsenite results in increased expression of NOX4 mRNA | PMID:27908234 | Nox4 | multiple interactions | ISO | Nox4 (Rattus norvegicus) | 6480464 | CTD | Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of NOX4 mRNA]; Grape Seed Extract inhibits the reaction [sodium arsenite results in increased expression of NOX4 protein]; Silybin inhibits the reaction [sodium arsenite results in increased expression of NOX4] | PMID:21605584 PMID:24062023 PMID:25218292 | Nox4 | multiple interactions | ISO | NOX4 (Homo sapiens) | 6480464 | CTD | NOX4 promotes the reaction [sodium arsenite inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]; NOX4 promotes the reaction [sodium arsenite results in increased abundance of Superoxides]; NOX4 protein promotes the reaction [sodium arsenite inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of HIF1A protein]]; NOX4 protein promotes the reaction [sodium arsenite results in increased activity of NFE2L2 protein]; NOX4 protein promotes the reaction [sodium arsenite results in increased expression of and results in increased activity of HIF1A protein]; NOX4 protein promotes the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]; NOX4 protein promotes the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein] | PMID:26535918 PMID:27286880 | | ||||||||||||||||||||||
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