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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731530
Species: Mus musculus
RGD Object: Gene
Symbol: Gper1
Name: G protein-coupled estrogen receptor 1
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gper1multiple interactionsISOGPER1 (Homo sapiens)6480464CTDGenistein binds to and results in increased activity of GPER1 protein; Genistein inhibits the reaction [bisphenol A results in decreased expression of GPER1 mRNA]; GPER1 protein affects the reaction [Genistein results in increased expression of FOS protein]PMID:15090535 PMID:17088055 PMID:32963737
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