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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731379
Species: Mus musculus
RGD Object: Gene
Symbol: Ptger3
Name: prostaglandin E receptor 3 (subtype EP3)
Acc ID: CHEBI:47519
Term: ketoconazole
Definition: A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.
Chemical ID: MESH:D007654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptger3increases expressionISOPtger3 (Rattus norvegicus)6480464CTDKetoconazole results in increased expression of PTGER3 mRNAPMID:37077353
Ptger3increases response to substanceISOPTGER3 (Homo sapiens)6480464CTDPTGER3 protein results in increased susceptibility to KetoconazolePMID:16784723
Ptger3multiple interactionsISOPTGER3 (Homo sapiens)6480464CTDPTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]PMID:16784723
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