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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730984
Species: Homo sapiens
RGD Object: Gene
Symbol: COL1A2
Name: collagen type I alpha 2 chain
Acc ID: CHEBI:67040
Term: S-adenosyl-L-methioninate
Definition: A sulfonium betaine that is a conjugate base of S-adenosyl-L-methionine obtained by the deprotonation of the carboxy group.
Chemical ID: MESH:D012436
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
COL1A2decreases expressionEXP 6480464CTDS-Adenosylmethionine results in decreased expression of COL1A2 mRNAPMID:15983038
COL1A2multiple interactionsISOCol1a2 (Rattus norvegicus)6480464CTDS-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]PMID:8878782
COL1A2multiple interactionsISOCol1a2 (Mus musculus)6480464CTDS-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]; S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein binds to COL1A2 promoter]PMID:15983038
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