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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730981
Species: Homo sapiens
RGD Object: Gene
Symbol: IL1B
Name: interleukin 1 beta
Acc ID: CHEBI:80852
Term: Morroniside
Definition: A glycoside that has formula C17H26O11.
Chemical ID: MESH:C488401
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL1Bmultiple interactionsISOIl1b (Mus musculus)6480464CTDmorroniside inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; morroniside inhibits the reaction [IL1B protein results in increased expression of CASP1]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of NLRP3]; morroniside inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of RELA protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]PMID:33022338 PMID:33804203 PMID:35279615
IL1Bmultiple interactionsISOIl1b (Rattus norvegicus)6480464CTDmorroniside inhibits the reaction [Glucose results in increased secretion of IL1B protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; S-4-bromobenzylglutathione cyclopentyl diester inhibits the reaction [morroniside inhibits the reaction [Glucose results in increased secretion of IL1B protein]]PMID:32643284 PMID:35279615
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