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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730945
Species: Mus musculus
RGD Object: Gene
Symbol: Abcb11
Name: ATP-binding cassette, sub-family B member 11
Acc ID: CHEBI:77249
Term: rosuvastatin calcium
Definition: An organic calcium salt that is the hemicalcium salt of rosuvastatin.
Chemical ID: MESH:D000068718
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb11multiple interactionsISOAbcb11 (Rattus norvegicus)6480464CTD[Cyclosporine results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [troglitazone results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin CalciumPMID:19853032
Abcb11multiple interactionsISOABCB11 (Homo sapiens)6480464CTDRosuvastatin Calcium inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]PMID:15901796
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