GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfkb1 | increases activity | EXP | | 6480464 | CTD | Ozone results in increased activity of NFKB1 protein | PMID:12162464 PMID:15064226 PMID:20826374 | Nfkb1 | increases expression | EXP | | 6480464 | CTD | Ozone results in increased expression of NFKB1 protein | PMID:15064226 PMID:26949510 | Nfkb1 | multiple interactions | EXP | | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ozone results in increased activity of [NFKB1 protein binds to RELA protein]]; IL10 gene mutant form promotes the reaction [Ozone results in increased activity of NFKB1 protein]; NFKB1 gene mutant form inhibits the reaction [Ozone promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]]; NFKB1 gene mutant form inhibits the reaction [Ozone results in decreased expression of IL10 protein]; NFKB1 gene mutant form inhibits the reaction [Ozone results in increased expression of NOS2 protein]; NFKB1 gene mutant form inhibits the reaction [Ozone results in increased expression of PTGS2 protein]; NFKB1 gene mutant form inhibits the reaction [Ozone results in increased expression of TNF protein]; NFKB1 protein promotes the reaction [[Ozone results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Ozone results in increased activity of [NFKB1 protein binds to RELA protein]; TNF protein affects the reaction [Ozone results in increased activity of [NFKB1 protein binds to RELA protein]]; wortmannin inhibits the reaction [Ozone results in increased activity of [NFKB1 protein binds to RELA protein]] | PMID:12162464 PMID:15064226 PMID:18207479 PMID:20826374 | Nfkb1 | affects expression | ISO | Nfkb1 (Rattus norvegicus) | 6480464 | CTD | Ozone affects the expression of NFKB1 mRNA | PMID:35112007 | Nfkb1 | increases expression | ISO | Nfkb1 (Rattus norvegicus) | 6480464 | CTD | Ozone results in increased expression of NFKB1 mRNA | PMID:16330353 | Nfkb1 | increases expression | ISO | NFKB1 (Homo sapiens) | 6480464 | CTD | Ozone results in increased expression of NFKB1 mRNA | PMID:31476115 | Nfkb1 | multiple interactions | ISO | NFKB1 (Homo sapiens) | 6480464 | CTD | [Aripiprazole co-treated with Ozone] results in increased expression of NFKB1 mRNA | PMID:31476115 | | ||||||||||||||||||||||
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