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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730872
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD2
Name: superoxide dismutase 2
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD2decreases activityEXP 6480464CTDRotenone results in decreased activity of SOD2 proteinPMID:30141137
SOD2decreases response to substanceEXP 6480464CTDSOD2 protein results in decreased susceptibility to RotenonePMID:18032788
SOD2increases expressionEXP 6480464CTDRotenone results in increased expression of SOD2 mRNA; Rotenone results in increased expression of SOD2 proteinPMID:32092105
SOD2multiple interactionsEXP 6480464CTD[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 mRNA; [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 protein; [Rotenone results in increased abundance of Superoxides] which results in increased expression of SOD2 protein; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [Rotenone results in increased expression of and results in increased activity of SOD2 protein]; Acetylcysteine inhibits the reaction [Rotenone results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [Rotenone results in increased expression of SOD2 protein]; fraxetin inhibits the reaction [Rotenone results in increased expression of and results in increased activity of SOD2 protein]; geraniol inhibits the reaction [Rotenone results in decreased activity of SOD2 protein]; Rotenone results in increased expression of and results in increased activity of SOD2 protein; SOD2 protein inhibits the reaction [Rotenone results in increased expression of BECN1 protein]PMID:15904944 PMID:16179351 PMID:18032788 PMID:30141137 PMID:32092105
SOD2affects activityISOSod2 (Mus musculus)6480464CTDRotenone affects the activity of SOD2 proteinPMID:32937126
SOD2decreases activityISOSod2 (Rattus norvegicus)6480464CTDRotenone results in decreased activity of SOD2 proteinPMID:25843018
SOD2decreases expressionISOSod2 (Mus musculus)6480464CTDRotenone results in decreased expression of SOD2 mRNAPMID:17657281
SOD2decreases expressionISOSod2 (Rattus norvegicus)6480464CTDRotenone results in decreased expression of SOD2 mRNA; Rotenone results in decreased expression of SOD2 proteinPMID:19818760 PMID:21807080 PMID:24036476
SOD2decreases response to substanceISOSod2 (Mus musculus)6480464CTDSOD2 protein results in decreased susceptibility to RotenonePMID:10463952
SOD2increases activityISOSod2 (Rattus norvegicus)6480464CTDRotenone results in increased activity of SOD2 proteinPMID:17079513 PMID:35253580
SOD2increases expressionISOSod2 (Rattus norvegicus)6480464CTDRotenone results in increased expression of SOD2 mRNA; Rotenone results in increased expression of SOD2 proteinPMID:17079513 PMID:35544339
SOD2multiple interactionsISOSod2 (Mus musculus)6480464CTDRotenone inhibits the reaction [Acetaminophen results in decreased expression of SOD2 mRNA]; Rotenone inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]PMID:30099449
SOD2multiple interactionsISOSod2 (Rattus norvegicus)6480464CTDAntiparkinson Agents inhibits the reaction [Rotenone results in decreased expression of SOD2 mRNA]; Plant Extracts inhibits the reaction [Rotenone results in increased activity of SOD2 protein]; Plant Extracts inhibits the reaction [Rotenone results in increased expression of SOD2 mRNA]; PQQ Cofactor inhibits the reaction [Rotenone results in decreased activity of SOD2 protein]; Quercetin analog inhibits the reaction [Rotenone results in increased activity of SOD2 protein]; Quercetin analog inhibits the reaction [Rotenone results in increased expression of SOD2 mRNA]; Quercetin inhibits the reaction [Rotenone results in increased activity of SOD2 protein]; Quercetin inhibits the reaction [Rotenone results in increased expression of SOD2 mRNA]PMID:17070561 PMID:17079513 PMID:21807080 PMID:25843018
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