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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730872
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD2
Name: superoxide dismutase 2
Acc ID: CHEBI:17243
Term: mono(2-ethylhexyl) phthalate
Definition: The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C016599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD2increases expressionEXP 6480464CTDmono-(2-ethylhexyl)phthalate results in increased expression of SOD2 mRNA; mono-(2-ethylhexyl)phthalate results in increased expression of SOD2 proteinPMID:33029813
SOD2multiple interactionsEXP 6480464CTDFOXO3 protein promotes the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of SOD2 mRNA]; FOXO3 protein promotes the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of SOD2 protein]PMID:33029813
SOD2decreases expressionISOSod2 (Rattus norvegicus)6480464CTDmono-(2-ethylhexyl)phthalate results in decreased expression of SOD2 mRNAPMID:32566080
SOD2increases expressionISOSod2 (Mus musculus)6480464CTDmono-(2-ethylhexyl)phthalate results in increased expression of SOD2 mRNA; mono-(2-ethylhexyl)phthalate results in increased expression of SOD2 proteinPMID:33360214 PMID:34627990
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