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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730872
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD2
Name: superoxide dismutase 2
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD2increases expressionEXP 6480464CTDQuercetin results in increased expression of SOD2 proteinPMID:22902249
SOD2multiple interactionsEXP 6480464CTD[pterostilbene co-treated with Quercetin] results in increased expression of SOD2 protein; Quercetin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD2 protein]; Quercetin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of SOD2 protein]; SP1 protein affects the reaction [[pterostilbene co-treated with Quercetin] results in increased expression of SOD2 protein]PMID:18852136 PMID:22902249 PMID:27050144
SOD2affects expressionISOSod2 (Rattus norvegicus)6480464CTDQuercetin affects the expression of SOD2 mRNA; Quercetin affects the expression of SOD2 proteinPMID:11543823
SOD2decreases expressionISOSod2 (Rattus norvegicus)6480464CTDQuercetin results in decreased expression of SOD2 mRNAPMID:12756520
SOD2increases expressionISOSod2 (Mus musculus)6480464CTDQuercetin results in increased expression of SOD2 mRNAPMID:23295412
SOD2multiple interactionsISOSod2 (Mus musculus)6480464CTD[Quercetin co-treated with Benzo(a)pyrene] results in increased expression of SOD2 mRNA; [Quercetin co-treated with Dietary Fats] results in decreased expression of SOD2 mRNA; Quercetin inhibits the reaction [Calcium Chloride results in increased activity of SOD2 protein]; Quercetin inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein]PMID:24337353 PMID:26887929 PMID:27260466 PMID:28533128
SOD2multiple interactionsISOSod2 (Rattus norvegicus)6480464CTDQuercetin affects the reaction [Atorvastatin affects the expression of SOD2 mRNA]; Quercetin analog inhibits the reaction [Rotenone results in increased activity of SOD2 protein]; Quercetin analog inhibits the reaction [Rotenone results in increased expression of SOD2 mRNA]; Quercetin inhibits the reaction [aluminum lactate results in increased expression of SOD2 mRNA]; Quercetin inhibits the reaction [aluminum lactate results in increased expression of SOD2 protein]; Quercetin inhibits the reaction [Atrazine results in decreased expression of SOD2 mRNA]; Quercetin inhibits the reaction [Rotenone results in increased activity of SOD2 protein]; Quercetin inhibits the reaction [Rotenone results in increased expression of SOD2 mRNA]; Quercetin promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with TNF protein] results in increased expression of SOD2 protein]PMID:16366677 PMID:17070561 PMID:17079513 PMID:21775390 PMID:23070809 PMID:26944603
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