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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:78420
Term: icariin
Definition: A member of the class of flavonols that is kaempferol which is substituted at position 8 by a 3-methylbut-2-en-1-yl group and in which the hydroxy groups at positions 3, 4', and 7 have been converted to the corresponding 6-deoxy-alpha-L-mannopyranoside, methyl ether, and beta-D-glucopyranoside, respectively. A phoshphodiesterase-5 inhibitor, it is obtained from several species of plants in the genus Epimedium and is thought to be the main active ingredient of the Chinese herbal medicine Herba Epimedii (yinyanghuo).
Chemical ID: MESH:C056599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relamultiple interactionsEXP 6480464CTDicariin inhibits the reaction [Cadmium results in increased expression of RELA mRNA]; icariin inhibits the reaction [Dietary Fats results in increased phosphorylation of RELA protein]; icariin inhibits the reaction [Fatty Acids, Nonesterified results in increased phosphorylation of RELA protein]PMID:37888945 PMID:39197519
Relaincreases activityISORELA (Homo sapiens)6480464CTDicariin results in increased activity of RELA proteinPMID:17499557
Relamultiple interactionsISORela (Mus musculus)6480464CTDicariin inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]; icariin results in increased expression of and affects the localization of RELA protein; SB 203580 inhibits the reaction [icariin results in increased expression of and affects the localization of RELA protein]; U 0126 inhibits the reaction [icariin results in increased expression of and affects the localization of RELA protein]PMID:18423597 PMID:20686223
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