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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:77986
Term: dibenziodolium
Definition: An organic cation that is fluorene in which the methylene group is replaced by a positively charged iodine.
Chemical ID: MESH:C007517
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relamultiple interactionsEXP 6480464CTDdiphenyleneiodonium inhibits the reaction [RELA protein binds to MMP9 promoter]; diphenyleneiodonium inhibits the reaction [TNF protein affects the localization of RELA protein]PMID:23774252
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDdiphenyleneiodonium inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of RELA protein modified form]; diphenyleneiodonium inhibits the reaction [Oxygen deficiency promotes the reaction [RELA protein binds to NFKB1 protein]]; diphenyleneiodonium inhibits the reaction [VEGFA protein affects the localization of RELA protein]PMID:11950692 PMID:15308628 PMID:19281832 PMID:27393034
Relamultiple interactionsISORela (Mus musculus)6480464CTDdiphenyleneiodonium inhibits the reaction [[Carmustine co-treated with Oligodeoxyribonucleotides analog] results in increased activity of [NFKB1 protein binds to RELA protein]]; diphenyleneiodonium inhibits the reaction [Endosulfan results in increased expression of RELA protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]PMID:12477282 PMID:19608869 PMID:25199686
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