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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:75142
Term: N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
Definition: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
Chemical ID: MESH:C072553
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Reladecreases expression EXP 401794136RGDMG132 pretreatment decreases expression of protein in liver of intestinal ischemia/reperfusion rats 
Relamultiple interactionsEXP 6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [halofuginone affects the localization of RELA protein]PMID:16489207
Relaaffects localizationISORELA (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the localization of RELA proteinPMID:23423712
Reladecreases activityISORELA (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased activity of RELA proteinPMID:15498850
Relaincreases activityISORELA (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of RELA proteinPMID:18457675
Relaincreases ubiquitinationISORELA (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of RELA proteinPMID:23401744
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of RELA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [(+)-JQ1 compound affects the localization of RELA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cisplatin promotes the reaction [RELA protein binds to TP63 protein alternative form]] which results in increased degradation of TP63 protein alternative form]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [BRD4 mutant form affects the localization of RELA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [CIGB-552 peptide results in decreased expression of RELA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Deoxycholic Acid results in increased localization of RELA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [EGF protein affects the localization of RELA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [trimethyltin chloride affects the localization of RELA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased activity of [NFKB1 protein binds to RELA protein]; SB 203580 inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of RELA protein]PMID:14527959 PMID:14581482 PMID:16026644 PMID:17644113 PMID:18457675 PMID:21088498 PMID:22766066 PMID:23401744 PMID:23423712 PMID:23686307
Relamultiple interactionsISORela (Mus musculus)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Zymosan affects the localization of RELA protein]PMID:11543732 PMID:12628480 PMID:12721113
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