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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:42588
Term: 4-hydroxyphenyl retinamide
Definition: A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.
Chemical ID: MESH:D017313
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaincreases expressionISORela (Mus musculus)6480464CTDFenretinide results in increased expression of RELA mRNAPMID:28973697
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDBortezomib promotes the reaction [Fenretinide inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Fenretinide inhibits the reaction [Hydrogen Peroxide results in increased activity of RELA protein]; Fenretinide inhibits the reaction [Okadaic Acid results in increased activity of RELA protein]; Fenretinide inhibits the reaction [pervanadate results in increased activity of RELA protein]; Fenretinide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]; Fenretinide inhibits the reaction [TNF protein results in increased activity of RELA protein]; Fenretinide inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]PMID:16230421
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