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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaaffects localizationEXP 6480464CTDBenzo(a)pyrene affects the localization of RELA proteinPMID:22051199 PMID:26358852
Relaincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of RELA proteinPMID:27206700
Relamultiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with Dibutyl Phthalate] results in increased expression of RELA mRNA; [Benzo(a)pyrene co-treated with Dibutyl Phthalate] results in increased expression of RELA protein; Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene affects the localization of RELA protein]; naringenin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein]PMID:22051199 PMID:27206700 PMID:36592837
Reladecreases expressionISORELA (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of RELA mRNAPMID:20106945
Relaincreases activityISORELA (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased activity of RELA proteinPMID:12393170
Relaincreases activityISORela (Mus musculus)6480464CTDBenzo(a)pyrene results in increased activity of RELA proteinPMID:27329536
Relaincreases expressionISORela (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of RELA mRNA; Benzo(a)pyrene results in increased expression of RELA proteinPMID:22228805 PMID:22369883 PMID:22610609 PMID:26546711 PMID:28032951 PMID:32061149 PMID:35567930
Relaincreases phosphorylationISORELA (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased phosphorylation of RELA proteinPMID:24431215 PMID:31154059
Relaincreases phosphorylationISORela (Mus musculus)6480464CTDBenzo(a)pyrene results in increased phosphorylation of RELA proteinPMID:35567930
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDalpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of RELA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of RELA protein]PMID:24431215
Relamultiple interactionsISORela (Mus musculus)6480464CTD[Lipopolysaccharides co-treated with Benzo(a)pyrene] results in increased activity of RELA protein; baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein]; Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein]; Docosahexaenoic Acids inhibits the reaction [[Lipopolysaccharides co-treated with Benzo(a)pyrene] results in increased activity of RELA protein]; Docosahexaenoic Acids inhibits the reaction [Benzo(a)pyrene results in increased activity of RELA protein]; hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein]; Plant Extracts inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein]PMID:22369883 PMID:26546711 PMID:27329536 PMID:28032951 PMID:32061149
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