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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:17594
Term: hydroquinone
Definition: A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.
Chemical ID: MESH:C031927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaaffects localizationISORELA (Homo sapiens)6480464CTDhydroquinone affects the localization of RELA proteinPMID:30090394
Relaincreases phosphorylationISORELA (Homo sapiens)6480464CTDhydroquinone results in increased phosphorylation of RELA proteinPMID:36646296
Relamultiple interactionsISORELA (Homo sapiens)6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [hydroquinone results in increased phosphorylation of RELA protein]; 4-phenylbutyric acid inhibits the reaction [hydroquinone results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased phosphorylation of RELA protein]; hydroquinone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and affects the localization of RELA protein]; hydroquinone inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]PMID:16928326 PMID:23288922 PMID:36646296
Relamultiple interactionsISORela (Mus musculus)6480464CTDhydroquinone inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; hydroquinone results in decreased activity of [NFKB1 protein binds to RELA protein]PMID:15894107 PMID:20054000
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