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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relamultiple interactionsEXP 6480464CTDProgesterone promotes the reaction [Hydrogen Peroxide results in increased activity of RELA protein]PMID:16284289
Reladecreases activityISORELA (Homo sapiens)6480464CTDProgesterone results in decreased activity of RELA proteinPMID:22615136
Reladecreases expressionISORELA (Homo sapiens)6480464CTDProgesterone results in decreased expression of RELA proteinPMID:17437195
Relaincreases expressionISORela (Mus musculus)6480464CTDProgesterone results in increased expression of RELA mRNAPMID:21549006
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDProgesterone inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Progesterone inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]PMID:15358673 PMID:22615136
Relamultiple interactionsISORela (Mus musculus)6480464CTDRELA affects the reaction [[monobutyl phthalate co-treated with CGB3 protein] results in increased secretion of Progesterone]; RELA affects the reaction [[monobutyl phthalate co-treated with Colforsin] results in increased secretion of Progesterone]; VIM inhibits the reaction [RELA affects the reaction [[monobutyl phthalate co-treated with CGB3 protein] results in increased secretion of Progesterone]]PMID:26745512
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