Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaincreases expressionEXP 6480464CTDEstradiol results in increased expression of RELA proteinPMID:36774993
Relamultiple interactionsEXP 6480464CTDEicosapentaenoic Acid inhibits the reaction [Estradiol results in increased expression of RELA protein]; Estradiol inhibits the reaction [RELA protein binds to NOS2 promoter]; Estradiol promotes the reaction [TERT protein binds to RELA protein]PMID:15590986 PMID:17053178 PMID:36774993
Relaincreases activityISORELA (Homo sapiens)6480464CTDEstradiol results in increased activity of RELA proteinPMID:16413991
Relaincreases expressionISORELA (Homo sapiens)6480464CTDEstradiol results in increased expression of RELA mRNAPMID:19401270
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDbisphenol A inhibits the reaction [Estradiol inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]]; Estradiol inhibits the reaction [IL1A protein promotes the reaction [[RELA protein binds to NFKB1 protein] which binds to CCL2 promoter]]; Estradiol inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; Estradiol inhibits the reaction [TNF protein promotes the reaction [RELA protein modified form binds to IL6 promoter]]; Estradiol inhibits the reaction [TNF protein results in increased activity of RELA protein]; Estradiol promotes the reaction [TNF protein results in increased activity of RELA protein]PMID:10614622 PMID:12574206 PMID:20600708 PMID:24771768
Relamultiple interactionsISORela (Mus musculus)6480464CTDEstradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of and results in increased phosphorylation of RELA protein]PMID:35537655
Go Back to source page   Continue to Ontology report