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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70884
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Acc ID: CHEBI:28901
Term: busulfan
Definition: A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant.
Chemical ID: MESH:D002066
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2ak3increases phosphorylationISOEif2ak3 (Mus musculus)6480464CTDBusulfan results in increased phosphorylation of EIF2AK3 proteinPMID:35533795
Eif2ak3multiple interactionsISOEif2ak3 (Mus musculus)6480464CTD4-phenylbutyric acid inhibits the reaction [Busulfan results in increased phosphorylation of EIF2AK3 protein]PMID:35533795
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