Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708428
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr1c3
Name: aldo-keto reductase family 1, member C3
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1c3affects expressionISOAkr1c18 (Mus musculus)6480464CTDsodium arsenite affects the expression of AKR1C18 mRNAPMID:16507464
Akr1c3decreases expressionISOAkr1c18 (Mus musculus)6480464CTDsodium arsenite results in decreased expression of AKR1C18 mRNAPMID:17350061
Akr1c3increases expressionISOAKR1C3 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of AKR1C3 mRNA; sodium arsenite results in increased expression of AKR1C3 proteinPMID:12727804 PMID:19696165 PMID:20886546 PMID:22714537 PMID:23876855 PMID:28595984 PMID:28713220 PMID:34032870 PMID:38568856
Akr1c3multiple interactionsISOAKR1C3 (Homo sapiens)6480464CTD[sodium arsenite results in increased abundance of arsenite] which results in increased expression of AKR1C3 mRNAPMID:32076005
Akr1c3multiple interactionsISOAkr1c18 (Mus musculus)6480464CTDsodium arsenite promotes the reaction [Diethylstilbestrol results in increased expression of AKR1C3 mRNA]PMID:19665456
Go Back to source page   Continue to Ontology report