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GENE - TERM ANNOTATION REPORT

RGD ID: 708380
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif2b5
Name: eukaryotic translation initiation factor 2B subunit epsilon
Acc ID: GO:0005085
Term: guanyl-nucleotide exchange factor activity
Definition: Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
Definition Source(s): GOC:kd, GOC:mah, PMID:23303910, PMID:27218782
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2b5 IDA 1581073RGD  
Eif2b5contributes_toIDA 1581075RGD  
Eif2b5contributes_toIDA 11041878RGD  
Eif2b5 IMP 1581085RGD  
Eif2b5contributes_toISOEIF2B5 (Homo sapiens)1624291RGD PMID:11323413

PMID:11323413
Eif2b5enablesISOEIF2B5 (Homo sapiens)1624291RGD PMID:15054402 PMID:25858979 PMID:27023709

PMID:15054402 PMID:25858979 PMID:27023709
Eif2b5enablesIBAFB:FBgn0023512 or PANTHER:PTN000500978 or SGD:S0000026191600115GO_CentralGO_REF:0000033

GO_REF:0000033
Eif2b5enablesIDA 1581073MGIPMID:9139680

 
Eif2b5enablesIDA 8553751MGIPMID:10858531

 
Eif2b5contributes_toISSUniProtKB:Q131441600115UniProtGO_REF:0000024

GO_REF:0000024
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