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Gene: EIF2B5 (eukaryotic translation initiation factor 2B subunit epsilon) Homo sapiens
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Symbol: EIF2B5
Name: eukaryotic translation initiation factor 2B subunit epsilon
Description: Contributes to guanyl-nucleotide exchange factor activity and translation initiation factor activity. Involved in several processes, including T cell receptor signaling pathway; glial cell development; and translational initiation. Localizes to the cytosol and eukaryotic translation initiation factor 2B complex. Implicated in leukoencephalopathy with vanishing white matter.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CACH; CLE; EIF-2B; eIF-2B GDP-GTP exchange factor subunit epsilon; EIF2Bepsilon; eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa; initiation factor eif-2be; LVWM; translation initiation factor eIF-2B subunit epsilon
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl3184,135,038 - 184,146,127 (+)Ensembl
GRCh383184,135,023 - 184,145,311 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373183,852,810 - 183,863,099 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,335,504 - 185,345,793 (+)NCBINCBI36hg18NCBI36
Build 343185,335,825 - 185,345,792NCBI
Celera3182,295,251 - 182,305,538 (+)NCBI
Cytogenetic Map3q27.1NCBI
HuRef3181,260,682 - 181,271,225 (+)NCBIHuRef
CHM1_13183,817,213 - 183,827,502 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on EIF2B5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731553
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-02-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.