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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:78671
Term: sodium chromate
Definition: An inorganic sodium salt consisting of sodium and chromate ions in a 2:1 ratio.
Chemical ID: MESH:C028982
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDsodium chromate(VI) results in increased phosphorylation of MAPK1 proteinPMID:14971655
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium chromate(VI) results in increased phosphorylation of MAPK1 protein]PMID:14971655
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased phosphorylation of MAPK1 protein; Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased phosphorylation of MAPK1 protein]PMID:35643323
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