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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:76290
Term: PhIP
Definition: An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Chemical ID: MESH:C049584
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases expressionISOMAPK1 (Homo sapiens)6480464CTD2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MAPK1 protein modified formPMID:15319301
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTD2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAPK1 proteinPMID:18056474 PMID:22307971
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDfulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MAPK1 protein modified form]; HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased phosphorylation of MAPK1 protein]PMID:15319301 PMID:22307971
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]PMID:18845389
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